An endosomal acid-regulatory feedback system rewires cytosolic cAMP metabolism and drives tumour progression

Although suppressed cAMP levels have been linked to cancer for nearly five decades, the molecular basis remains uncertain. Here, we identify endosomal pH as a novel regulator of cytosolic cAMP homeostasis and a promoter of transformed phenotypic traits in colorectal cancer (CRC). Combining experimen...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Mol Cancer Res
Glavni autori: Prasad, Hari, Mandal, Susmita, Mathew, John Kandam Kulathu, Cherukunnath, Aparna, Duddu, Atchuta Srinivas, Banerjee, Mallar, Ramani, Harini, Bhat, Ramray, Jolly, Mohit Kumar, Visweswariah, Sandhya S.
Format: Artigo
Jezik:Inglês
Izdano: 2024
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617132/
https://ncbi.nlm.nih.gov/pubmed/38319300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-23-0606
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items