Delta-24-RGD, an oncolytic adenovirus, increases survival and promotes proinflammatory immune landscape remodeling in models of AT/RT and CNS-PNET

PURPOSE: Atypical teratoid/rhabdoid tumors (AT/RTs) and primitive neuroectodermal tumors (CNS-PNETs) are pediatric brain tumors with poor survival and life-long negative side effects. Here, the aim was to characterize the efficacy and safety of the oncolytic adenovirus Delta-24-RGDs, which selective...

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Publicado no:Clin Cancer Res
Main Authors: Garcia-Moure, Marc, Gonzalez-Huarriz, Marisol, Labiano, Sara, Guruceaga, Elizabeth, Bandrés, Eva, Zalacain, Marta, Marrodan, Lucía, de Andrea, Carlos, Villalba, Maria, Martinez-Vélez, Naiara, Laspidea, Virginia, Puigdelloses, Montse, Perez-Larraya, Jaime Gallego, Iñigo-Marco, Ignacio, Stripecke, Renata, Chan, Jennifer A, Raabe, Eric H, Kool, Marcel, Gomez-Manzano, Candelaria, Fueyo, Juan, Patiño-García, Ana, Alonso, Marta M
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617079/
https://ncbi.nlm.nih.gov/pubmed/33376098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3313
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