Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory

Osteosarcoma is an aggressive bone tumor occurring primarily in pediatric patients. Despite years of intensive research, the outcomes of patients with metastatic disease or those who do not respond to therapy have remained poor and have not changed in the last 30 years. Oncolytic virotherapy is beco...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Martinez-Velez, Naiara, Laspidea, Virginia, Zalacain, Marta, Labiano, Sara, García-Moure, Marc, Puigdelloses, Montse, Marrodan, Lucía, Gonzalez-Huarriz, Marisol, Herrador, Guillermo, de la Nava, Daniel, Ausejo-Mauleon, Iker, Fueyo, Juan, Gomez-Manzano, Candelaria, Patiño-García, Ana, Alonso, Marta M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2022
Assuntos:
Models and Technologies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612474/
https://ncbi.nlm.nih.gov/pubmed/34965961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-21-0565
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