Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels

Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and heart failure in the elderly. A feared side effect of sodium channel blocker therapy, ventricular pro-arrhythmia, appears to be relatively rare in patients with AF. The biophysical reasons for this relati...

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Bibliographic Details
Published in:J Mol Cell Cardiol
Main Authors: O’ Brien, Sian, Holmes, Andrew P., Johnson, Daniel M., Kabir, S. Nashitha, O’ Shea, Christopher, O’ Reilly, Molly, Avezzu, Adelisa, Reyat, Jasmeet S., Hall, Amelia W., Apicella, Clara, Ellinor, Patrick T., Niederer, Steven, Tucker, Nathan R., Fabritz, Larissa, Kirchhof, Paulus, Pavlovic, Davor
Format: Artigo
Language:Inglês
Published: 2022
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616974/
https://ncbi.nlm.nih.gov/pubmed/35114252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2022.01.009
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