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Unravelling the role of amino acid sequence order in the assembly and function of the amyloid-β core†
The amino acid sequence plays an essential role in amyloid for-mation. Here, using the central core recognition module of the Aβ peptide and its reverse sequence, we show that although both peptides assemble into β-sheets, their morphologies, kinetics and cell toxicities display marked differences....
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| Опубликовано в: : | Chem Commun (Camb) |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616937/ https://ncbi.nlm.nih.gov/pubmed/31276123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc03654g |
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