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Unravelling the role of amino acid sequence order in the assembly and function of the amyloid-β core†

The amino acid sequence plays an essential role in amyloid for-mation. Here, using the central core recognition module of the Aβ peptide and its reverse sequence, we show that although both peptides assemble into β-sheets, their morphologies, kinetics and cell toxicities display marked differences....

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Dades bibliogràfiques
Publicat a:Chem Commun (Camb)
Autors principals: Bera, Santu, Arad, Elad, Schnaider, Lee, Shaham-Niv, Shira, Castelletto, Valeria, Peretz, Yossef, Zaguri, Dor, Jelinek, Raz, Gazit, Ehud, Hamley, Ian W.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616937/
https://ncbi.nlm.nih.gov/pubmed/31276123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc03654g
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