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Unravelling the role of amino acid sequence order in the assembly and function of the amyloid-β core†
The amino acid sequence plays an essential role in amyloid for-mation. Here, using the central core recognition module of the Aβ peptide and its reverse sequence, we show that although both peptides assemble into β-sheets, their morphologies, kinetics and cell toxicities display marked differences....
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| 出版年: | Chem Commun (Camb) |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616937/ https://ncbi.nlm.nih.gov/pubmed/31276123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc03654g |
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