Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages

In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactivation (XCI). Although Polycomb repressive complex (PRC) 1 and PRC2 have both been implicated in gene silencing, their exact roles in XCI during in vivo development have remained elusive. To...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Masuil, Osamu, Corbel, Catherine, Nagao, Koji, Endo, Takaho A., Kezuka, Fuyuko, Diabangouaya, Patricia, Nakayama, Manabu, Kumon, Mami, Koseki, Yoko, Obuse, Chikashi, Koseki, Haruhiko, Heard, Edith
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2023
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616894/
https://ncbi.nlm.nih.gov/pubmed/36635505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-01047-y
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