Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with ‘cigarette smoking initiation’ really capturing?

Genetic variants used as instruments for exposures in Mendelian randomisation (MR) analyses may have horizontal pleiotropic effects (i.e., influence outcomes via pathways other than through the exposure), which can undermine the validity of results. We examined the extent of this using smoking behav...

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Bibliografische gegevens
Gepubliceerd in:Genet Epidemiol
Hoofdauteurs: Reed, Zoe E., Wootton, Robyn E., Khouja, Jasmine N., Richardson, Tom G., Sanderson, Eleanor, Davey Smith, George, Munafò, Marcus R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2024
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616876/
https://ncbi.nlm.nih.gov/pubmed/39099143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22583
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