Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

OBJECTIVE: To evaluate whether body size in early life has an independent effect on risk of disease in later life or whether its influence is mediated by body size in adulthood. DESIGN: Two sample univariable and multivariable mendelian randomisation. SETTING: The UK Biobank prospective cohort study...

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Publicat a:BMJ
Autors principals: Richardson, Tom G, Sanderson, Eleanor, Elsworth, Benjamin, Tilling, Kate, Davey Smith, George
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group Ltd. 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201936/
https://ncbi.nlm.nih.gov/pubmed/32376654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmj.m1203
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