Chargement en cours...

Exploring pleiotropy in Mendelian randomisation analyses: What are genetic variants associated with ‘cigarette smoking initiation’ really capturing?

Genetic variants used as instruments for exposures in Mendelian randomisation (MR) analyses may have horizontal pleiotropic effects (i.e., influence outcomes via pathways other than through the exposure), which can undermine the validity of results. We examined the extent of this using smoking behav...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Genet Epidemiol
Auteurs principaux: Reed, Zoe E., Wootton, Robyn E., Khouja, Jasmine N., Richardson, Tom G., Sanderson, Eleanor, Davey Smith, George, Munafò, Marcus R.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2024
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616876/
https://ncbi.nlm.nih.gov/pubmed/39099143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22583
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!