Aggregate-selective removal of pathological tau via clustering-activated degraders

Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase TRIM21 degrades antibody-bound proteins in an assembly state-specific manner, owing to the requirement of TRIM21 RING domain clustering for activation, yet effective...

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Foilsithe in:Science
Main Authors: Benn, Jonathan, Cheng, Shi, Keeling, Sophie, Smith, Annabel E, Vaysburd, Marina J, Böken, Dorothea, Miller, Lauren VC, Katsinelos, Taxiarchis, Franco, Catarina, Dupré, Elian, Danis, Clément, Landrieu, Isabelle, Buée, Luc, Klenerman, David, James, Leo C, McEwan, William A
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2024
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616837/
https://ncbi.nlm.nih.gov/pubmed/39208111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adp5186
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