Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here, we describe a therapeutic strategy called “RING-Bait,” which employs an aggregating protein sequence combined with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Miller, Lauren V.C., Papa, Guido, Vaysburd, Marina, Cheng, Shi, Sweeney, Paul W., Smith, Annabel, Franco, Catarina, Katsinelos, Taxiarchis, Huang, Melissa, Sanford, Sophie A.I., Benn, Jonathan, Farnsworth, Jasmine, Higginson, Katie, Joyner, Holly, McEwan, William A., James, Leo C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2024
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616835/
https://ncbi.nlm.nih.gov/pubmed/39276772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2024.08.024
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