Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models

Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. Tau can be targeted using passively transferred antibodies (Abs) but the mechanisms of Ab protection are incompletely understood. Here we used a variety of cell and animal model systems and showed that th...

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Vydáno v:Science
Hlavní autoři: Mukadam, Aamir S, Miller, Lauren VC, Smith, Annabel E, Vaysburd, Marina, Sakya, Siri A, Sanford, Sophie, Keeling, Sophie, Tuck, Benjamin J, Katsinelos, Taxiarchis, Green, Chris, Skov, Lise, Kaalund, Sanne S, Foss, Stian, Mayes, Keith, O’Connell, Kevin, Wing, Mark, Knox, Claire, Banbury, Jessica, Avezov, Edward, Rowe, James B, Goedert, Michel, Andersen, Jan Terje, James, Leo C, McEwan, William A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2023
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614512/
https://ncbi.nlm.nih.gov/pubmed/36996217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abn1366
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