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Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function
Protein aggregation causes a wide range of neurodegenerative diseases. Targeting and removing aggregates, but not the functional protein, is a considerable therapeutic challenge. Here, we describe a therapeutic strategy called “RING-Bait,” which employs an aggregating protein sequence combined with...
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| 出版年: | Cell |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2024
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616835/ https://ncbi.nlm.nih.gov/pubmed/39276772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2024.08.024 |
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