Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

Alzheimer’s disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports transcellular transfer of tau misfolding (seeding) as the mechanism of spread within an affected brain, a process reminiscent...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: McEwan, William A., Falcon, Benjamin, Vaysburd, Marina, Clift, Dean, Oblak, Adrian L., Ghetti, Bernardino, Goedert, Michel, James, Leo C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255578/
https://ncbi.nlm.nih.gov/pubmed/28049840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607215114
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