Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders

Adenovirus-derived nanoparticles (ADDomer) comprise 60 copies of adenovirus penton base protein (PBP). ADDomer is thermostable, rendering the storage, transport, and deployment of ADDomer-based therapeutics independent of a cold chain. To expand the scope of ADDomers for new applications, we enginee...

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Publicat a:Structure
Autors principals: Buzas, Dora, Sun, Huan, Toelzer, Christine, Yadav, Sathish K.N., Borucu, Ufuk, Gautam, Gunjan, Gupta, Kapil, Bufton, Joshua C., Capin, Julien, Sessions, Richard B., Garzoni, Frederic, Berger, Imre, Schaffitzel, Christiane
Format: Artigo
Idioma:Inglês
Publicat: 2024
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616808/
https://ncbi.nlm.nih.gov/pubmed/38198950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2023.12.010
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