Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery

The dense stromal matrix in fibrotic tumors hinders tumor-targeted drug delivery. Tamoxifen (TMX), an estrogen receptor modulator that is clinically used for the treatment of breast cancer, has been shown to reprogram the tumor microenvironment (TME) and to alleviate desmoplasia. We here investigate...

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Publicado en:Adv Ther (Weinh)
Autores principales: Biancacci, Ilaria, De Santis, Daniele, Rama, Elena, Benderski, Karina, Momoh, Jeffrey, Pohlberger, Robert, Moeckel, Diana, Kaps, Leonard, Rijcken, Cristianne JF, Prakash, Jai, Thewissen, Marielle, Kiessling, Fabian, Shi, Yang, Peña, Quim, Sofias, Alexandros Marios, Consolino, Lorena, Lammers, Twan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2023
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616667/
https://ncbi.nlm.nih.gov/pubmed/39376929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202300098
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