Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery

The dense stromal matrix in fibrotic tumors hinders tumor-targeted drug delivery. Tamoxifen (TMX), an estrogen receptor modulator that is clinically used for the treatment of breast cancer, has been shown to reprogram the tumor microenvironment (TME) and to alleviate desmoplasia. We here investigate...

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Vydáno v:Adv Ther (Weinh)
Hlavní autoři: Biancacci, Ilaria, De Santis, Daniele, Rama, Elena, Benderski, Karina, Momoh, Jeffrey, Pohlberger, Robert, Moeckel, Diana, Kaps, Leonard, Rijcken, Cristianne JF, Prakash, Jai, Thewissen, Marielle, Kiessling, Fabian, Shi, Yang, Peña, Quim, Sofias, Alexandros Marios, Consolino, Lorena, Lammers, Twan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2023
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616667/
https://ncbi.nlm.nih.gov/pubmed/39376929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202300098
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