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Transient excited states of the metamorphic protein Mad2 and their implications for function

The spindle checkpoint complex is a key surveillance mechanism in cell division that prevents premature separation of sister chromatids. Mad2 is an integral component of this spindle checkpoint complex that recognizes cognate substrates such as Mad1 and Cdc20 in its closed (C-Mad2) conformation by f...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Jain, Shefali, Sekhar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: 2025
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616478/
https://ncbi.nlm.nih.gov/pubmed/38221646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.26667
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