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Protein Metamorphosis: The Two-State Behavior of Mad2
A given protein generally has only one native tertiary fold, which is the conformation with the lowest Gibbs free energy. Mad2, a protein involved in the spindle checkpoint, however, has two natively folded states with similar Gibbs free energies. Through binding to its target Cdc20, Mad2 inhibits t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644451/ https://ncbi.nlm.nih.gov/pubmed/19000814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.002 |
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