No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated

HIV-1 group M (HIV-1M) lineages downregulate HLA-I and CD4 expression via their Nef proteins. We hypothesized that these Nef functions may be partially responsible for the differences in prevalence of viruses from different lineages that co-circulate within an epidemic. Here, we characterized these...

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Udgivet i:Front Virol
Main Authors: Sonela, Nelson, Mann, Jaclyn, Godwe, Celestin, Goni, Oumarou H., Tchakoute, Mérime, Nkoue, Nathalie, de Oliveira, Tulio, Brockman, Mark A., Brumme, Zabrina L., Ndung’u, Thumbi, Tongo, Marcel
Format: Artigo
Sprog:Inglês
Udgivet: 2024
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616105/
https://ncbi.nlm.nih.gov/pubmed/38883214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fviro.2024.1379217
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