Isothiourea-Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6- and 1,4-Additions

The enantioselective α-functionalisation of glycine Schiff base aryl esters through isothiourea catalysis is successfully demonstrated for 1,6-additions to para-quinone methides (21 examples, up to 95:5 dr and 96:4 er) and 1,4-additions to methylene substituted dicarbonyl or disulfonyl Michael accep...

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Publicado en:ChemistryEurope
Autores principales: Stockhammer, Lotte, Craik, Rebecca, Monkowius, Uwe, Cordes, David B., Smith, Andrew D., Waser, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: 2023
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616101/
https://ncbi.nlm.nih.gov/pubmed/38882579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ceur.202300015
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