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Live-cell photo-activated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca(2+) sparks constitute the fundamental units of Ca(2+) release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively generate these events by employing a transgenic mouse with a photo-activated label on RyR2. This allowed correlative imaging of RyR localization, by sup...
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| Pubblicato in: | Nat Cardiovasc Res |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2023
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616007/ https://ncbi.nlm.nih.gov/pubmed/38803363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s44161-022-00199-2 |
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