Treosulfan Exposure Predicts Thalassemia-Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation

A toxicity-reduced conditioning regimen with treosulfan, fludarabine, and thiotepa in patients with high-risk β-thalassemia major has significantly improved hematopoietic stem cell transplantation (HCT) outcomes. However, complications resulting from regimen-related toxicities (RRTs), mixed chimeris...

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Published in:Clin Pharmacol Ther
Main Authors: Pai, Aswin Anand, Mohanan, Ezhilpavai, Panetta, John C., Kulkarni, Uday P., Illangeswaran, Raveen Stephen Stallon, Balakrishnan, Balaji, Jayaraman, Agila, Edison, Eunice S., Lakshmi, Kavitha M., Devasia, Anup J., Fouzia, Nambiathayil Aboobacker, Korula, Anu, Abraham, Aby, George, Biju, Srivastava, Alok, Mathews, Vikram, Standing, Joseph F., Balasubramanian, Poonkuzhali
Format: Artigo
Language:Inglês
Published: 2024
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615782/
https://ncbi.nlm.nih.gov/pubmed/37846495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.3078
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