The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner

The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis. Such autoimmu...

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Publicado no:Front Trop Dis
Main Authors: Harnett, Margaret M., Doonan, James, Tarafdar, Anuradha, Pineda, Miguel A., Duncombe-Moore, Josephine, Buitrago, Geraldine, Pan, Piaopiao, Hoskisson, Paul A., Selman, Colin, Harnett, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615750/
https://ncbi.nlm.nih.gov/pubmed/38500783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fitd.2023.1334705
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