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The point mutation γ2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABA(A) receptor subtypes
Benzodiazepine site agonists or inverse agonists enhance or reduce γ-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition of neurons, respectively. Recently, it was demonstrated that the point mutation γ2F77I causes a drastic change in the affinity of a variety of benzodiazepine agonists or i...
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| Publicado no: | Eur J Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7615656/ https://ncbi.nlm.nih.gov/pubmed/20303942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.03.015 |
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