The point mutation γ2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABA(A) receptor subtypes

Benzodiazepine site agonists or inverse agonists enhance or reduce γ-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition of neurons, respectively. Recently, it was demonstrated that the point mutation γ2F77I causes a drastic change in the affinity of a variety of benzodiazepine agonists or i...

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發表在:Eur J Pharmacol
Main Authors: Ramerstorfer, Joachim, Furtmüller, Roman, Vogel, Elisabeth, Huck, Sigismund, Sieghart, Werner
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615656/
https://ncbi.nlm.nih.gov/pubmed/20303942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.03.015
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