NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis

Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology of MAFLD is the development of non-alcoholic steatohepatitis (NASH), which can potentially lead to fibrosis and hepatocellular carc...

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Vydáno v:Sci Immunol
Hlavní autoři: Marinović, Sonja, Lenartić, Maja, Mladenić, Karlo, Šestan, Marko, Kavazović, Inga, Benić, Ante, Krapić, Mia, Rindlisbacher, Lukas, Brdovčak, Maja Cokarić, Sparano, Colin, Litscher, Gioana, Wensveen, Tamara Turk, Mikolašević, Ivana, Čupić, Dora Fučkar, Bilić-Zulle, Lidija, Steinle, Aleksander, Waisman, Ari, Hayday, Adrian, Tugues, Sonia, Becher, Burkhard, Polić, Bojan, Wensveen, Felix M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2023
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615627/
https://ncbi.nlm.nih.gov/pubmed/37774007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.add1599
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