Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells

The human CD8(+) T cell clone 6C5 has previously been shown to recognize the tert-butyl-modified Bax(161–170) peptide LLSY(3-tBu)FGTPT presented by HLA-A*0201. This non-natural epitope was likely created as a by-product of fluorenylmethoxycarbonyl protecting group (Fmoc) peptide synthesis and bound...

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Veröffentlicht in:J Immunol
Hauptverfasser: Man, Stephen, Redman, James E., Cross, Deborah, Cole, David K., Can, Ilona, Davies, Bethan, Hashimdeen, Shaikh Shimaz, Reid, Reiss, Llewellyn-Lacey, Sian, Miners, Kelly L., Ladell, Kristin, Lissina, Anya, Brown, Paul E., Wooldridge, Linda, Price, David A., Rizkallah, Pierre J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615501/
https://ncbi.nlm.nih.gov/pubmed/34321228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000756
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