T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation

The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and expressing the master transcription factor RORγt. Accordingly, RORγt-deficient mice lack ILC3 and lymphoid structures, including lymph nodes (L...

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Publié dans:Nat Immunol
Auteurs principaux: Stehle, Christina, Rückert, Timo, Fiancette, Rémi, Gajdasik, Dominika W., Willis, Claire, Ulbricht, Carolin, Durek, Pawel, Mashreghi, Mir-Farzin, Finke, Daniela, Hauser, Anja Erika, Withers, David R., Chang, Hyun-Dong, Zimmermann, Jakob, Romagnani, Chiara
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614953/
https://ncbi.nlm.nih.gov/pubmed/34556887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01029-6
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