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RNA recording in single bacterial cells using reprogrammed tracrRNAs
Capturing an individual cell’s transcriptional history is a challenge exacerbated by the functional heterogeneity of cellular communities. Here, we leverage reprogrammed tracrRNAs (Rptrs) to record selected cellular transcripts as stored DNA edits in single living bacterial cells. Rptrs are designed...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group US
2023
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614944/ https://ncbi.nlm.nih.gov/pubmed/36604543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-022-01604-8 |
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