RNA recording in single bacterial cells using reprogrammed tracrRNAs

Capturing an individual cell’s transcriptional history is a challenge exacerbated by the functional heterogeneity of cellular communities. Here, we leverage reprogrammed tracrRNAs (Rptrs) to record selected cellular transcripts as stored DNA edits in single living bacterial cells. Rptrs are designed...

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Publicado en:Nat Biotechnol
Autores principales: Jiao, Chunlei, Reckstadt, Claas, König, Fabian, Homberger, Christina, Yu, Jiaqi, Vogel, Jörg, Westermann, Alexander J., Sharma, Cynthia M., Beisel, Chase L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group US 2023
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614944/
https://ncbi.nlm.nih.gov/pubmed/36604543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-022-01604-8
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