RNA recording in single bacterial cells using reprogrammed tracrRNAs

Capturing an individual cell’s transcriptional history is a challenge exacerbated by the functional heterogeneity of cellular communities. Here, we leverage reprogrammed tracrRNAs (Rptrs) to record selected cellular transcripts as stored DNA edits in single living bacterial cells. Rptrs are designed...

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Pubblicato in:Nat Biotechnol
Autori principali: Jiao, Chunlei, Reckstadt, Claas, König, Fabian, Homberger, Christina, Yu, Jiaqi, Vogel, Jörg, Westermann, Alexander J., Sharma, Cynthia M., Beisel, Chase L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2023
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614944/
https://ncbi.nlm.nih.gov/pubmed/36604543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-022-01604-8
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