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Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I. Cross-presentation relies on the unique “leakiness” of endocytic compartments in DCs, whereby internalised proteins escape into the cytosol for prote...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2023
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614779/ https://ncbi.nlm.nih.gov/pubmed/37347855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adg8802 |
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