Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I. Cross-presentation relies on the unique “leakiness” of endocytic compartments in DCs, whereby internalised proteins escape into the cytosol for prote...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Rodríguez-Silvestre, Pablo, Laub, Marco, Krawczyk, Patrycja A., Davies, Alexandra K., Schessner, Julia P., Parveen, Reejuana, Tuck, Benjamin J., McEwan, William A., Borner, Georg H.H., Kozik, Patrycja
Format: Artigo
Jezik:Inglês
Izdano: 2023
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614779/
https://ncbi.nlm.nih.gov/pubmed/37347855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.adg8802
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