Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization

Crossing the blood-brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding of the mechanisms of cancer cell extravasation from brain microcapillaries is limited as the underlying cellular and molecular processes cannot be adequately investigated using in vitro models and en...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Karreman, Matthia A., Bauer, Alexander T., Solecki, Gergely, Berghoff, Anna S., Mayer, Chanté D., Frey, Katharina, Hebach, Nils, Feinauer, Manuel J., Schieber, Nicole L., Tehranian, Cedric, Mercier, Luc, Singhal, Mahak, Venkataramani, Varun, Schubert, Marc C., Hinze, Daniel, Hölzel, Michael, Helfrich, Iris, Schadendorf, Dirk, Schneider, Stefan W., Westphal, Dana, Augustin, Hellmut G., Goetz, Jacky G., Schwab, Yannick, Wick, Wolfgang, Winkler, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2023
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614438/
https://ncbi.nlm.nih.gov/pubmed/36652557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-22-3964
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