NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

RATIONALE: Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant responses and disease pathogenesis has yet to be ful...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Ryan, Eilise M., Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R., Zhang, Ailiang, Howden, Andrew J. M., Sanchez-Garcia, Manuel A., Bewley, Martin, Cole, Joby, McHugh, Brian J., Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, Von Kriegsheim, Alex, Sanchez, Yolanda, Rumsey, William, Callahan, James F., Cooper, George, Parkinson, Nicholas, Baillie, Kenneth, Cantrell, Doreen A., McCafferty, John, Choudhury, Gourab, Singh, Dave, Dockrell, David H., Whyte, Moira K. B., Walmsley, Sarah R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2023
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614437/
https://ncbi.nlm.nih.gov/pubmed/36724365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.202203-0482OC
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