In vivo prime editing of a metabolic liver disease in mice

Prime editing is a highly versatile CRISPR-based genome editing technology that works without DNA double-strand break formation. Despite rapid technological advances, in vivo application for the treatment of genetic diseases remains challenging. Here, we developed a size-reduced SpCas9 prime editor...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Transl Med
Egile Nagusiak: Böck, Desirée, Rothgangl, Tanja, Villiger, Lukas, Schmidheini, Lukas, Matsushita, Mai, Mathis, Nicolas, Ioannidi, Eleonora, Rimann, Nicole, Grisch-Chan, Hiu Man, Kreutzer, Susanne, Kontarakis, Zacharias, Kopf, Manfred, Thöny, Beat, Schwank, Gerald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2022
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614134/
https://ncbi.nlm.nih.gov/pubmed/35294257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abl9238
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak