Crescents derive from single podocyte progenitors and a drug enhancing their differentiation attenuates crescentic glomerulonephritis*

Crescentic glomerulonephritis is characterized by vascular necrosis and the formation of parietal epithelial cell (PEC) hyperplasia, but little is known about the molecular mechanisms driving this process. Inducing crescentic glomerulonephritis in several Pax2Cre reporter mouse lines revealed that c...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Melica, Maria Elena, Antonelli, Giulia, Semeraro, Roberto, Angelotti, Maria Lucia, Lugli, Gianmarco, Landini, Samuela, Ravaglia, Fiammetta, La Regina, Gilda, Conte, Carolina, De Chiara, Letizia, Peired, Anna Julie, Mazzinghi, Benedetta, Donati, Marta, Molli, Alice, Steiger, Stefanie, Magi, Alberto, Bartalucci, Niccolò, Raglianti, Valentina, Guzzi, Francesco, Maggi, Laura, Annunziato, Francesco, Burger, Alexa, Lazzeri, Elena, Anders, Hans-Joachim, Lasagni, Laura, Romagnani, Paola
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614034/
https://ncbi.nlm.nih.gov/pubmed/35947676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abg3277
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