Crescents derive from single podocyte progenitors and a drug enhancing their differentiation attenuates crescentic glomerulonephritis*

Crescentic glomerulonephritis is characterized by vascular necrosis and the formation of parietal epithelial cell (PEC) hyperplasia, but little is known about the molecular mechanisms driving this process. Inducing crescentic glomerulonephritis in several Pax2Cre reporter mouse lines revealed that c...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Melica, Maria Elena, Antonelli, Giulia, Semeraro, Roberto, Angelotti, Maria Lucia, Lugli, Gianmarco, Landini, Samuela, Ravaglia, Fiammetta, La Regina, Gilda, Conte, Carolina, De Chiara, Letizia, Peired, Anna Julie, Mazzinghi, Benedetta, Donati, Marta, Molli, Alice, Steiger, Stefanie, Magi, Alberto, Bartalucci, Niccolò, Raglianti, Valentina, Guzzi, Francesco, Maggi, Laura, Annunziato, Francesco, Burger, Alexa, Lazzeri, Elena, Anders, Hans-Joachim, Lasagni, Laura, Romagnani, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614034/
https://ncbi.nlm.nih.gov/pubmed/35947676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abg3277
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