An αvβ3 integrin checkpoint is critical for efficient T(H)2 cytokine polarisation and potentiating antigen-specific immunity

Naïve CD4(+) T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focussed modular cytokine responses. Interleukin (IL)-4-induced Ga...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Szeto, Aydan C. H., Ferreira, Ana C. F., Mannion, Jonathan, Clark, Paula A., Sivasubramaniam, Meera, Heycock, Morgan W. D., Crisp, Alastair, Jolin, Helen E., Kozik, Patrycja, Knolle, Martin D., McKenzie, Andrew N. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614022/
https://ncbi.nlm.nih.gov/pubmed/36550322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-022-01378-w
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