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RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2 can arise in the embryonic thymus, from shared T cell precursors, preceding the emergence of CD4(+)CD8(+) (double-positive) T cells. Thymic ILC2 migra...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116838/ https://ncbi.nlm.nih.gov/pubmed/33432227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-00833-w |
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