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Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

In recent years, platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response, for example, due to dysfunctional BRCA1. Despite this knowledge, we are still missing helpful markers to predict Pt response in the clinic. We have p...

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Vydáno v:Cancer Res Commun
Hlavní autoři: Widmer, Carmen A., Klebic, Ismar, Domanitskaya, Natalya, Decollogny, Morgane, Howald, Denise, Siffert, Myriam, Essers, Paul, Nowicka, Zuzanna, Stokar-Regenscheit, Nadine, van de Ven, Marieke, de Korte-Grimmerink, Renske, Galván, José A., Pritchard, Colin E.J., Huijbers, Ivo J., Fendler, Wojciech, Vens, Conchita, Rottenberg, Sven
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for Cancer Research 2022
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613873/
https://ncbi.nlm.nih.gov/pubmed/36467895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2767-9764.CRC-22-0208
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