Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration

BACKGROUND & AIMS: In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signaling. The bone morphogenetic protein (BMP) pathway has a physiological, prodifferentiation role, predominantly inferred through previous experimental pathway inactivation. Intestinal reg...

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Publicado no:Gastroenterology
Main Authors: Koppens, Martijn A. J., Davis, Hayley, Valbuena, Gabriel N., Mulholland, Eoghan J., Nasreddin, Nadia, Colombe, Mathilde, Antanaviciute, Agne, Biswas, Sujata, Friedrich, Matthias, Lee, Lennard, Wang, Lai Mun, Koelzer, Viktor H., East, James E., Simmons, Alison, Winton, Douglas J., Leedham, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613733/
https://ncbi.nlm.nih.gov/pubmed/33819486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2021.03.052
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