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Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration

BACKGROUND & AIMS: In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signaling. The bone morphogenetic protein (BMP) pathway has a physiological, prodifferentiation role, predominantly inferred through previous experimental pathway inactivation. Intestinal reg...

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Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Koppens, Martijn A. J., Davis, Hayley, Valbuena, Gabriel N., Mulholland, Eoghan J., Nasreddin, Nadia, Colombe, Mathilde, Antanaviciute, Agne, Biswas, Sujata, Friedrich, Matthias, Lee, Lennard, Wang, Lai Mun, Koelzer, Viktor H., East, James E., Simmons, Alison, Winton, Douglas J., Leedham, Simon J.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613733/
https://ncbi.nlm.nih.gov/pubmed/33819486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2021.03.052
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