An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

The common view is that T-lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily naïve and central memory cells) elongated telomeres by acquiring telomere vesicles from antigen-presenting cells (APCs) independently of telomerase action. Upon contact with these...

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Publicado no:Nat Cell Biol
Main Authors: Lanna, Alessio, Vaz, Bruno, D’Ambra, Clara, Valvo, Salvatore, Vuotto, Claudia, Chiurchiù, Valerio, Devine, Oliver, Sanchez, Massimo, Borsellino, Giovanna, Akbar, Arne N., De Bardi, Marco, Gilroy, Derek W., Dustin, Michael L., Blumer, Brendan, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613731/
https://ncbi.nlm.nih.gov/pubmed/36109671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-00991-z
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