Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery

While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently undruggable targets which could potentially be treated with RNA therapeutics. Hence, local, pulmonary delivery of RNA nanoparticles could finally enable delivery beyond the liver. The administration of R...

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Détails bibliographiques
Publié dans:J Control Release
Auteurs principaux: Zimmermann, Christoph M, Baldassi, Domizia, Chan, Karen, Adams, Nathan B. P., Neumann, Alina, Porras-Gonzalez, Diana Leidy, Wei, Xin, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Burgstaller, Gerald, Witzigmann, Dominik, Luciani, Paola, Merkel, Olivia M
Format: Artigo
Langue:Inglês
Publié: 2022
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613708/
https://ncbi.nlm.nih.gov/pubmed/36126785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2022.09.021
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