Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles

To develop stable and inhalable dry powder formulations with long shelf life, we spray dried polyplexes consisting of siRNA and a polyethylenimine based block copolymer in presence of mannitol or trehalose. We investigated the effect of inlet (T-In) and outlet (T-Out) temperature on the recovery of...

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Bibliografiske detaljer
Udgivet i:Adv Ther (Weinh)
Main Authors: Keil, Tobias WM, Zimmermann, Christoph, Baldassi, Domizia, Adams, Friederike, Friess, Wolfgang, Mehta, Aditi, Merkel, Olivia M
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611418/
https://ncbi.nlm.nih.gov/pubmed/34337144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202100073
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