Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery

While all the siRNA drugs on the market target the liver, the lungs offer a variety of currently undruggable targets which could potentially be treated with RNA therapeutics. Hence, local, pulmonary delivery of RNA nanoparticles could finally enable delivery beyond the liver. The administration of R...

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Bibliographic Details
Published in:J Control Release
Main Authors: Zimmermann, Christoph M, Baldassi, Domizia, Chan, Karen, Adams, Nathan B. P., Neumann, Alina, Porras-Gonzalez, Diana Leidy, Wei, Xin, Kneidinger, Nikolaus, Stoleriu, Mircea Gabriel, Burgstaller, Gerald, Witzigmann, Dominik, Luciani, Paola, Merkel, Olivia M
Format: Artigo
Language:Inglês
Published: 2022
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613708/
https://ncbi.nlm.nih.gov/pubmed/36126785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2022.09.021
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