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Target site selection and remodeling by type V CRISPR-transposon systems
Canonical CRISPR-Cas systems provide adaptive immunity against mobile genetic elements(1). However, type I-F, I-B and V-K systems have been adopted by Tn7-like transposons to direct RNA-guided transposon insertion(2–7). Type V-K CRISPR-associated transposons rely on the pseudonuclease Cas12k, the tr...
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| Publié dans: | Nature |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7613401/ https://ncbi.nlm.nih.gov/pubmed/34759315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-04030-z |
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