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In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

Transplantation of B cells engineered ex vivo to secrete broadly neutralizing antibodies (bNAbs) has shown efficacy in disease models. However, clinical translation of this approach would require specialized medical centers, technically demanding protocols and MHC compatibility of donor cells and re...

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Dades bibliogràfiques
Publicat a:Nat Biotechnol
Autors principals: Nahmad, A. D., Lazzarotto, C. R., Zelikson, N., Kustin, T., Tenuta, M., Huang, D., Reuveni, I., Nataf, D., Raviv, Y., Horovitz-Fried, M., Dotan, I., Carmi, Y., Rosin-Arbesfeld, R., Nemazee, D., Voss, J.E., Stern, A., Tsai, S. Q., Barzel, A.
Format: Artigo
Idioma:Inglês
Publicat: 2022
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613293/
https://ncbi.nlm.nih.gov/pubmed/35681059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-022-01328-9
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