Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens

Cancer associated gene fusions (GF) are a potential source for highly immunogenic neo-antigens, but the lack of computational tools for accurate, sensitive identification of personal GFs has limited their targeting in personalized cancer immunotherapy. Here, we present EasyFuse, a machine learning c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Biotechnol
Prif Awduron: Weber, D, Ibn-Salem, J, Sorn, P, Suchan, M, Holtsträter, C, Lahrmann, U, Vogler, I, Schmoldt, K, Lang, F, Schrörs, B, Löwer, M, Sahin, U
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2022
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613288/
https://ncbi.nlm.nih.gov/pubmed/35379963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-022-01247-9
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